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Effects of GLP

Abstract Agonists targeting the receptors of incretin hormones , glucagon-like peptide-1 and glucose-dependent insulinotropic peptide, have been well established for the treatment of type 2 diabetes mellitus. There is increasing awareness that gastroenterologists and hepatologists should be treating obesity when patients present to their clinics.

Glucagon-like peptide-1 ( GLP-1 ) is an incretin hormone released from gut enteroendocrine cells that modulates glucose metabolism by controlling insulin excretion and glucagon secretion and inhibits gastric emptying leading to decreased food intake, thus limiting weight gain. GLP-1 receptor agonists ( GLP-1 RAs) mimic GLP-1's effects on gastric function. In light of the promising evidence ...

Centrally, GLP-1 RAs modulate brain regions controlling appetite, influencing neurotransmitter and peptide release to regulate hunger and energy expenditure. Peripherally, GLP-1 RAs improve glycemic control by enhancing insulin secretion, reducing glucagon release, delaying gastric emptying, and regulating gut hormones .

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This review collates current evidence on the microbiome-mediated modulation of GLP-1 dynamics, evaluates the pharmacomicrobiomic impact of GLP-1 agonists and outlines future research directions at the interface of gut microbiota and incretin biology.

Exploring the Impact of GLP

Explore the effects of GLP-1 on gut health and the microbiota. Discover how this hormone influences inflammation and barrier integrity for a healthier digestive system.

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Demonstrating the important roles of GLP-1 analogs and GLP-1 receptor agonists in the modern therapy of type 2 diabetes and obesity, and given their complex pathophysiology, including potential changes in the gut microbiome environment, we undertook to examine the current state of knowledge on the effects of the cited drugs on the state of the ...

Gut microbiome may shape response to GLP

This review examines how GLP-1 receptor agonists and the gut microbiome influence one another through bile acid signaling, short-chain fatty acids, and inflammatory pathways. It explores how ...

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The availability of glucagon-like peptide-1 ( GLP-1 ) receptor agonists (RAs) such as liraglutide and semaglutide, and a GLP-1 and glucose dependent insulinotropic polypeptide coagonist (tirzepatide) represents a paradigm shift in the management of both type 2 diabetes and obesity. There is now considerable attention, including in the public media, on the effect of both long-acting and short ...

Purpose of Review This review summarizes the current understanding of the physiologic influence of GLP-1 RAs on gastrointestinal motility, highlights key clinical implications of these effects, and defines areas for future investigation. Recent Findings Glucagon-like peptide-1 receptor agonists ( GLP-1 RAs) have revolutionized the treatment of diabetes and obesity and are increasingly being ...

Glucagon (GCG) like peptide 1 ( GLP-1 ) has emerged as a powerful player in regulating metabolism and a promising therapeutic target for various chronic diseases. This review delves into the physiological roles of GLP-1 , exploring its impact on ...

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