Efficacy and Safety of GLP
This systematic review and meta-analysis assesses the efficacy and safety of glucagon-like peptide-1 receptor agonists ( GLP-1 RAs) in children and adolescents with obesity, prediabetes, or type 2 diabetes.
Key Details About Generally Asymptomatic Glp-1 Deficiency Adolescents
Which GLP-1 Medications Are Approved for Adolescents Three GLP-1 receptor agonists currently have pediatric or adolescent approvals in the United States, with distinct indications and age cutoffs.
Glucagon-like peptide-1 receptor agonists ( GLP -1RAs) have surged to the forefront of obesity treatment due to their efficacy in weight loss and weight management across age groups, including among adolescents [ 1 ]. However, there is limited evidence on how the use of GLP -1RAs for obesity during adolescence may impact this critical developmental period and long-term health. There is an urgent ...

This study examines the prescribing of glucagon-like peptide-1 receptor agonists for adolescents with obesity and associated disparities.
Obesity remains highly prevalent among children in the United States and is associated with an ever-increasing burden of obesity-related diseases. Effective pediatric obesity prevention and treatment will require both societal interventions and health care system innovation. One recent advancement is the approval of glucagon-like peptide-1 receptor agonists ( GLP -1RAs) for use in adolescents ...
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Abstract Disclosure: G. Castano: None. S. Sisley: None. Background: Glucagon-like-peptide-1 agonists ( GLP1 ), approved for adolescents ≥ 10 years in 2019 for type 2 diabetes (T2D) and ≥ 12 years in 2020 for obesity, require adequate dose titration and have known side effects. There is little information on insurance approval, adherence to titration regimens, or the side effects of ...

Glucagon-like peptide-1-receptor agonists ( GLP-1s ) have emerged as a promising treatment for children and adolescents with obesity or type 2 diabetes, although concerns about real-world safety — including risk for depression and suicidality — have been raised. A new meta-analysis of 18 randomized, controlled trials comparing GLP-1s with placebo assessed 23 different efficacy and safety ...
Efficacy and safety of GLP
Abstract: Importance: Obesity affects 1 in 5 children and adolescents , increasing the risk of type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists ( GLP-1 RAs) are among the few pharmacotherapy options available for this population, necessitating a comprehensive evaluation of efficacy and safety.
The authors have provided us with clinically relevant data indicating the effectiveness of GLP-1 RAs in the treatment of children and adolescents with T2D and/or obesity.
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