Calcium Co
Background: Nutrients stimulate calcium dependent activation of energy metabolism , in pancreatic beta cells. Results: Glucose-induced ATP synthase-dependent respiration is strictly calcium - dependent , with little or no effect of calcium on the ...
Our findings challenge the current view, which has focused mainly on calcium -sensitive dehydrogenases as the target for the activation of mitochondrial energy metabolism . We propose a model of tight calcium - dependent regulation of oxidative metabolism and ATP synthase-dependent respiration in beta cell mitochondria.
Calcium Co
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A model of tight calcium - dependent regulation of oxidative metabolism and ATP synthase-dependent respiration in beta cell mitochondria is proposed, which challenges the current view, which has focused mainly on calcium -sensitive dehydrogenases as the target for the activation of mitochondrial energy metabolism . Background: Nutrients stimulate calcium dependent activation of energy metabolism ...
These steady-state [Ca 2+] m levels are suggested to regulate the metabolic energy supply due to Ca 2+ - dependent regulation of mitochondrial enzymes of the tricarboxylic acid cycle (TCA), the proteins of the electron transport chain (ETC), and the F 1 F 0 ATP synthase itself.
Regulation of ATP production by mitochondrial Ca2
Stimulation of mitochondrial oxidative metabolism by Ca 2+ is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca 2+ regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in ...
Here, we analyze the efficiency of ATP production by the tricarboxylic acid cycle and oxidative phosphorylation, which generate most of the chemical energy in eukaryotes. Calcium signaling regulates this pathway and can affect its energetic output, but the concrete energetic impact of this cross-talk remains elusive.
Regulation of ATP production
Nanomolar free calcium enhances oxidative phosphorylation. However, the effects over a broad concentration range, at different respiratory states, or on specific energy substrates are less clear. We examined the action of varying [Ca2+] over respiratory states ranging 4 to 3 on skeletal muscle mitochondrial respiration, potential, ATP production, and H2O2 production using ADP recycling to ...
The latter process couples the oxidation of reduced cofactors via the respiratory chain to ATP synthesis by mitochondrial ATP synthase . The supply of reduced cofactors (NADH, FADH 2) is ensured by mitochondrial oxidation of substrates derived from glucose, fatty acids, and amino acids via different metabolic pathways.
